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README.md

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+# Model Files for the Paper
+
+Ratte S, Prescott SA (2011) ClC-2 Channels Regulate Neuronal Excitability, Not Intracellular Chloride Levels *J Neurosci* 31(44):15838-15843
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+These model files were supplied by Dr Steve Prescott.
+
+## Models
+
+- **ClC2-VClamp-Prescott.ode** implements simulations in voltage clamp. Data presented in Figure 1 of the paper can be reproduced using this model.
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+- **ClC2-IClamp-Prescott.ode** implements simulations in current clamp. Data presented in Figures 2 and 3 of the paper can be reproduced using this model.
+
+## Model Description
+
+The model is for a generic, single compartment neuron with multiple ion currents. The most notable mechanisms include ClC-2 (a rectifying chloride-leak channel) and KCC2 (potassium chloride co-transporter 2). A significant feature of the model is that it tracks intracellular chloride concentration. Moreover, the GABA-A receptor is modeled as passing both chloride and bicarbonate ions, which is important for proper calculation of the GABA reversal potential. Ornstein-Uhlenbeck processes to simulate synaptic inhibition and excitation are also included.
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+2025-06-20: Converted README to Markdown.