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30 changes: 16 additions & 14 deletions readme.html → README.md
Original file line number Diff line number Diff line change
@@ -1,11 +1,10 @@
<html><pre>
This is the readme for the model associated with the papers:
# This is the readme for the model associated with the papers:

Ref: Laventovich and Hemkin, A mathematical model of spontaneous
calcium(II) oscillations in astrocytes. J Theor Biol 2008;
calcium(II) oscillations in astrocytes. *J Theor Biol* 2008;
251(4):553-60.

Abstract:
## Abstract:

Astrocytes exhibit oscillations and waves of Ca2+ ions within their
cytosol and it appears that this behavior helps facilitate the
Expand All @@ -21,23 +20,26 @@
mimicking experimental constraints we have found that this model
provides results that are qualitatively similar to experiment.

To run the model:
## To run the model:

Expand the archive and cd into the newly created directory and run:
xppaut Ca-Oscil-Astrocyte.ode
`xppaut Ca-Oscil-Astrocyte.ode`
then click on Initialcond -> Go

<img src="./Glia-Oscill.JPG" alt="screenshot">
![screenshot](./Glia-Oscill.JPG)

This simulation will make graphs similar to the paper of Laventovich
and Hemkin. Note that the cytosolic calcium concentration shown in
and Hemkin. Note that the cytosolic calcium concentration shown in
figure 3 of the paper should be increased by 10-fold.

The model file was supplied by:
## The model file was supplied by:

Dr. Sheng-Nan Wu
Cardiac Electrophysiology and Systems-biology Center (CESC)
National Cheng Kung University Medical College
Tainan 70101, Taiwan
Dr. Sheng-Nan Wu
Cardiac Electrophysiology and Systems-biology Center (CESC)
National Cheng Kung University Medical College
Tainan 70101, Taiwan
e-mail: snwu@mail.ncku.edu.tw
</pre></html>

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2025-06-02: Standardized to Markdown.