From a43b3e3df3ab0f630207d366e04777978386a437 Mon Sep 17 00:00:00 2001 From: EnfxcFCb6 Date: Fri, 20 Jun 2025 17:02:40 -0400 Subject: [PATCH 1/2] Standardized README to Markdown format --- README.md | 23 +++++++++++++++++++++++ readme.txt | 25 ------------------------- 2 files changed, 23 insertions(+), 25 deletions(-) create mode 100644 README.md delete mode 100644 readme.txt diff --git a/README.md b/README.md new file mode 100644 index 0000000..bdb460e --- /dev/null +++ b/README.md @@ -0,0 +1,23 @@ +# Model Files for the Paper + +Ratte S, Prescott SA (2011) ClC-2 Channels Regulate Neuronal +Excitability, Not Intracellular Chloride Levels *J Neurosci* +31(44):15838-15843 + +These model files were supplied by Dr Steve Prescott. + +## Models + +- **ClC2-VClamp-Prescott.ode** implements simulations in voltage clamp. + Data presented in Figure 1 of the paper can be reproduced using this model. + +- **ClC2-IClamp-Prescott.ode** implements simulations in current clamp. + Data presented in Figures 2 and 3 of the paper can be reproduced using this model. + +## Model Description + +The model is for a generic, single compartment neuron with multiple ion currents. The most notable mechanisms include ClC-2 (a rectifying chloride-leak channel) and KCC2 (potassium chloride co-transporter 2). A significant feature of the model is that it tracks intracellular chloride concentration. Moreover, the GABA-A receptor is modeled as passing both chloride and bicarbonate ions, which is important for proper calculation of the GABA reversal potential. Ornstein-Uhlenbeck processes to simulate synaptic inhibition and excitation are also included. + +--- + +2025-06-20: Converted README to Markdown. \ No newline at end of file diff --git a/readme.txt b/readme.txt deleted file mode 100644 index 8b6610f..0000000 --- a/readme.txt +++ /dev/null @@ -1,25 +0,0 @@ -This is the readme for the model files for the paper: - -Ratte S, Prescott SA (2011) ClC-2 Channels Regulate Neuronal -Excitability, Not Intracellular Chloride Levels J Neurosci -31(44):15838-15843 - -These model files were supplied by Dr Steve Prescott. - -ClC2-VClamp-Prescott.ode implements simulations in voltage clamp. -Data presented in Figure 1 of the paper can be reproduced using this -model - -ClC2-IClamp-Prescott.ode implements simulations in current clamp. -Data presented in Figures 2 and 3 of the paper can be reproduced using -this model. - -The model is for a generic, single compartment neuron with multiple -ion currents. The most notable mechanisms include ClC-2 (a rectifying -chloride-leak channel) and KCC2 (potassium chloride co-transporter 2). -A significant feature of the model is that it tracks intracellular -chloride concentration. Moreover, the GABA-A receptor is modeled as -passing both chloride and bicarbonate ions, which is important for -proper calculation of the GABA reversal potential. Ornstein-Unlenbeck -processes to simulate synaptic inhibition and excitation are also -included. From 81da28a074e8c37742d4ef7c560305c79af1aa1e Mon Sep 17 00:00:00 2001 From: rsakai Date: Mon, 7 Jul 2025 14:44:55 -0400 Subject: [PATCH 2/2] Update README.md --- README.md | 12 ++++-------- 1 file changed, 4 insertions(+), 8 deletions(-) diff --git a/README.md b/README.md index bdb460e..c087124 100644 --- a/README.md +++ b/README.md @@ -1,18 +1,14 @@ # Model Files for the Paper -Ratte S, Prescott SA (2011) ClC-2 Channels Regulate Neuronal -Excitability, Not Intracellular Chloride Levels *J Neurosci* -31(44):15838-15843 +Ratte S, Prescott SA (2011) ClC-2 Channels Regulate Neuronal Excitability, Not Intracellular Chloride Levels *J Neurosci* 31(44):15838-15843 These model files were supplied by Dr Steve Prescott. ## Models -- **ClC2-VClamp-Prescott.ode** implements simulations in voltage clamp. - Data presented in Figure 1 of the paper can be reproduced using this model. +- **ClC2-VClamp-Prescott.ode** implements simulations in voltage clamp. Data presented in Figure 1 of the paper can be reproduced using this model. -- **ClC2-IClamp-Prescott.ode** implements simulations in current clamp. - Data presented in Figures 2 and 3 of the paper can be reproduced using this model. +- **ClC2-IClamp-Prescott.ode** implements simulations in current clamp. Data presented in Figures 2 and 3 of the paper can be reproduced using this model. ## Model Description @@ -20,4 +16,4 @@ The model is for a generic, single compartment neuron with multiple ion currents --- -2025-06-20: Converted README to Markdown. \ No newline at end of file +2025-06-20: Converted README to Markdown.